Infectious salmon anemia virus--genetics and pathogenesis.
Identifieur interne : 000513 ( Main/Exploration ); précédent : 000512; suivant : 000514Infectious salmon anemia virus--genetics and pathogenesis.
Auteurs : Luis Cottet [Chili] ; Andrea Rivas-Aravena ; Marcelo Cortez-San Martin ; Ana María Sandino ; Eugenio SpencerSource :
- Virus research [ 1872-7492 ] ; 2011.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Canada, Chili, Flambées de maladies, Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (virologie), Infections à Orthomyxoviridae (épidémiologie), Isavirus (génétique), Isavirus (pathogénicité), Maladies des poissons (virologie), Norvège, Polymorphisme génétique, Protéines virales (génétique), Salmo salar (virologie), Virulence, Écosse, États-Unis d'Amérique.
- MESH :
- génétique : ARN viral, Isavirus, Protéines virales.
- médecine vétérinaire : Infections à Orthomyxoviridae.
- pathogénicité : Isavirus.
- virologie : Infections à Orthomyxoviridae, Maladies des poissons, Salmo salar.
- épidémiologie : Infections à Orthomyxoviridae.
- Animaux, Canada, Chili, Flambées de maladies, Norvège, Polymorphisme génétique, Virulence, Écosse, États-Unis d'Amérique.
- Wicri :
- geographic : Canada, Chili, Norvège, États-Unis.
English descriptors
- KwdEn :
- Animals, Canada, Chile, Disease Outbreaks, Fish Diseases (virology), Isavirus (genetics), Isavirus (pathogenicity), Norway, Orthomyxoviridae Infections (epidemiology), Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Polymorphism, Genetic, RNA, Viral (genetics), Salmo salar (virology), Scotland, United States, Viral Proteins (genetics), Virulence.
- MESH :
- chemical , genetics : RNA, Viral, Viral Proteins.
- geographic : Canada, Chile, Norway, Scotland, United States.
- epidemiology : Orthomyxoviridae Infections.
- genetics : Isavirus.
- pathogenicity : Isavirus.
- veterinary : Orthomyxoviridae Infections.
- virology : Fish Diseases, Orthomyxoviridae Infections, Salmo salar.
- Animals, Disease Outbreaks, Polymorphism, Genetic, Virulence.
Abstract
The infectious salmon anemia virus (ISAV) is the causative agent of the ISA syndrome that affects mainly Atlantic salmon (Salmo salar) and has caused high mortality epidemics in Norway, Scotland, Canada, the United States and Chile. It is classified as an Orthomyxoviridae, its genome is composed of 8 single-strand RNA segments with negative polarity that code for 11 polypeptides. Through functional studies of the coded proteins it has been established that RNA segments 5 and 6 code for a fusion protein and hemagglutinin, respectively, while two polypeptides coded by segments 7 and 8 inhibit interferon induction. The functions of the rest of the possible proteins coded by the viral genome have been assigned by comparison with the corresponding ones of the influenza virus genome. As to its pathogenicity, some growth parameters such as incubation period, resistance to chemical and physical factors, establishment of the infection in other marine species, and dissemination ability among the different organs have been evaluated in several salmonids. Genomic analysis has shown (i) the existence of a high polymorphism region (HPR) in segment 6, and (ii) sequence insertion in segment 5. More than 20 HPR variants have been determined, all originating from HPR0, which is associated with low pathogenicity, while 4 different sequence insertions in segment 5 have not been related with some characteristic of the virus infection. Much progress has been made in the characterization of the virus in 20 years of study, but more detailed knowledge of the specific function of the proteins coded by all the viral genes is still missing, including the pathogenicity mechanism at the molecular level.
DOI: 10.1016/j.virusres.2010.10.021
PubMed: 20979983
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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It is classified as an Orthomyxoviridae, its genome is composed of 8 single-strand RNA segments with negative polarity that code for 11 polypeptides. Through functional studies of the coded proteins it has been established that RNA segments 5 and 6 code for a fusion protein and hemagglutinin, respectively, while two polypeptides coded by segments 7 and 8 inhibit interferon induction. The functions of the rest of the possible proteins coded by the viral genome have been assigned by comparison with the corresponding ones of the influenza virus genome. As to its pathogenicity, some growth parameters such as incubation period, resistance to chemical and physical factors, establishment of the infection in other marine species, and dissemination ability among the different organs have been evaluated in several salmonids. Genomic analysis has shown (i) the existence of a high polymorphism region (HPR) in segment 6, and (ii) sequence insertion in segment 5. More than 20 HPR variants have been determined, all originating from HPR0, which is associated with low pathogenicity, while 4 different sequence insertions in segment 5 have not been related with some characteristic of the virus infection. Much progress has been made in the characterization of the virus in 20 years of study, but more detailed knowledge of the specific function of the proteins coded by all the viral genes is still missing, including the pathogenicity mechanism at the molecular level.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20979983</PMID><DateCompleted><Year>2011</Year><Month>04</Month><Day>04</Day></DateCompleted><DateRevised><Year>2010</Year><Month>12</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7492</ISSN><JournalIssue CitedMedium="Internet"><Volume>155</Volume><Issue>1</Issue><PubDate><Year>2011</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Virus research</Title><ISOAbbreviation>Virus Res.</ISOAbbreviation></Journal><ArticleTitle>Infectious salmon anemia virus--genetics and pathogenesis.</ArticleTitle><Pagination><MedlinePgn>10-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.virusres.2010.10.021</ELocationID><Abstract><AbstractText>The infectious salmon anemia virus (ISAV) is the causative agent of the ISA syndrome that affects mainly Atlantic salmon (Salmo salar) and has caused high mortality epidemics in Norway, Scotland, Canada, the United States and Chile. It is classified as an Orthomyxoviridae, its genome is composed of 8 single-strand RNA segments with negative polarity that code for 11 polypeptides. Through functional studies of the coded proteins it has been established that RNA segments 5 and 6 code for a fusion protein and hemagglutinin, respectively, while two polypeptides coded by segments 7 and 8 inhibit interferon induction. The functions of the rest of the possible proteins coded by the viral genome have been assigned by comparison with the corresponding ones of the influenza virus genome. As to its pathogenicity, some growth parameters such as incubation period, resistance to chemical and physical factors, establishment of the infection in other marine species, and dissemination ability among the different organs have been evaluated in several salmonids. Genomic analysis has shown (i) the existence of a high polymorphism region (HPR) in segment 6, and (ii) sequence insertion in segment 5. More than 20 HPR variants have been determined, all originating from HPR0, which is associated with low pathogenicity, while 4 different sequence insertions in segment 5 have not been related with some characteristic of the virus infection. Much progress has been made in the characterization of the virus in 20 years of study, but more detailed knowledge of the specific function of the proteins coded by all the viral genes is still missing, including the pathogenicity mechanism at the molecular level.</AbstractText><CopyrightInformation>Copyright © 2010 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cottet</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratorio de Virología, Facultad de Química y Biología, Universidad de Santiago de Chile, Centro de Biotecnología Acuícola, Avenida Libertador Bernardo O'Higgins, 3363 Santiago, Chile. luis.cottetb@usach.cl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivas-Aravena</LastName><ForeName>Andrea</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Cortez-San Martin</LastName><ForeName>Marcelo</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Sandino</LastName><ForeName>Ana María</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Spencer</LastName><ForeName>Eugenio</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal 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MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>05</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>10</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>10</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>10</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20979983</ArticleId><ArticleId IdType="pii">S0168-1702(10)00380-1</ArticleId><ArticleId IdType="doi">10.1016/j.virusres.2010.10.021</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Chili</li></country></list><tree><noCountry><name sortKey="Cortez San Martin, Marcelo" sort="Cortez San Martin, Marcelo" uniqKey="Cortez San Martin M" first="Marcelo" last="Cortez-San Martin">Marcelo Cortez-San Martin</name><name sortKey="Rivas Aravena, Andrea" sort="Rivas Aravena, Andrea" uniqKey="Rivas Aravena A" first="Andrea" last="Rivas-Aravena">Andrea Rivas-Aravena</name><name sortKey="Sandino, Ana Maria" sort="Sandino, Ana Maria" uniqKey="Sandino A" first="Ana María" last="Sandino">Ana María Sandino</name><name sortKey="Spencer, Eugenio" sort="Spencer, Eugenio" uniqKey="Spencer E" first="Eugenio" last="Spencer">Eugenio Spencer</name></noCountry><country name="Chili"><noRegion><name sortKey="Cottet, Luis" sort="Cottet, Luis" uniqKey="Cottet L" first="Luis" last="Cottet">Luis Cottet</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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